For most of the game, you should have it set to double speed, making it easier to watch your progress. However, when you buy a load of transmission modifications, set Infection 2 to normal speeds so that it’s easier to jump from place to place and collect DNA as needed. Then when the DNA popups slow down again, set the game back to double speed.
The whole game is more difficult to beat than the first Infection was, but hard and frenzy modes are especially difficult. To beat the difficult modes, start the game and then don’t buy a single thing. Let the DNA build up for a long time until it is at least 200, if not 300. Then, buy all of the transmissions and all of the resistances and let everybody get infected extremely rapidly. Once every country is infected, then start purchasing loads of the symptoms.
The reason this works where other strategies fail is that when you don’t have any transmission purchases, countries will not begin curing the disease, even on hard mode. This allows you to literally set the game aside for as long as you want and let the DNA build up. The only things that stop you are news bulletin popups.
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Plus, the more symptoms you have, the faster the cure percentage will increase. It’s better to purchase everything all at once so that when you purchase all of the transmissions, the disease spreads faster than it can be contained, and when you buy all of the symptoms at once, people will die off faster than they can be cured.
To unlock new virii, beat the current disease on either medium mode or hard mode. Medium mode is recommended because it’s far easier to win on medium mode. Hard mode, however, gives you a higher chance of gems popping up, and free
gems allow you to purchase free bonuses.
Pay attention to the news popups, because they will give you valuable information that will lead to more success when you use the right strategy. For example, if temperatures around the world are dropping, the effectiveness of transmissions, resistances and symptoms that affect cold areas will increase, and the effectiveness of things that affect hot areas will decrease.